Trimix Injection

Trimix Injection


TriMix is administered as a penile self-injection, typically considered to be the most powerful class of anti-erectile dysfunction agents. While the components of TriMix Injection (Papaverine, Phentolamine, Prostaglandin E1) are, on their own, indicated for a vast number of different conditions, the practice of bringing them together in concert to treat erectile dysfunction has become commonplace in sexual medicine.

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Recommended Dosage5-10 minutes prior to sexual activity and not more than twice a week. Not to be used twice within 24 hours

*Medical Prescription Required

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What is Trimix Injection?

Trimix is an injectable prescription medicine used for the treatment of erectile dysfunction. It consists of 3 active ingredients: Papaverine, Phentolamine and Prostaglandin E1, which increase blood flow to the penis and provide a firm erection. It is usually used as an alternative to PDE-5 inhibitors. That’s why Trimix Injection is best suited for men who are not able to take PDE-5 medicines as treatment for erectile dysfunction.

How Does Trimix Injection Work?

Trimix Injection contains three medicines from complementary classes designed to act synergically, mixed into a sterile injection. They are –


  • A medicine that causes blood vessels to expand (vasodilator).
  • It produces an erection by allowing for increased blood flow to the penis.
  • Experimental data, performed in-vitro, displays papaverine acting to relax the penile arteries, the cavernosal sinusoids, and the penile veins.


  • When injected into the penis, it induces an erection by relaxing and dilating the blood vessels of the penis, as well as by elevating cardiac output.
  • Side effects of phentolamine are rare.

Prostaglandin E1

  • A potent hormone-like substance that induces erection by relaxing the penis’s blood vessels and dilating cavernosal arteries-dilation of the cavernosal arteries.
  • It is accompanied by increased arterial inflow velocity and increased venous outflow resistance allowing for more blood into the penis and less blood out.

How & When to Use Trimix Injections:

  • Ideally, the trimix injections should be administered just prior to foreplay.
  • It is administered via intracavernosal injection and should produce an erection in 5 to 20 minutes and can be expected to last up to one hour.
  • To prevent bruising, apply firm pressure to the injection site for 5 minutes after injecting.
  • Do not use TriMix Injection more than two times a week; use at least 24 hours apart.
  • There is a possibility of needle breakage with the use of TriMix Injection: you should pay careful attention to your doctor’s instructions and handle the syringe and needle properly.

Side-Effects of Trimix:

  • Mild to moderate pain during injection; painful sensation with erection; small amount of bleeding at the injection site.
  • Call your healthcare provider if you notice any redness, lumps, swelling, tenderness or curvature of the erect penis.
  • If you experience an erection lasting more than 2 hours, you may take 2 – 4 pseudoephedrine 30 mg by mouth once and apply an ice pack.
  • If your erection does not go away within the next hour, seek professional help immediately. Erections that last more than 6 hours can cause serious damage to the penile tissue.

How to Store Trimix Injection:

Store dry powder at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Once reconstituted keep trimix injections in a refrigerator between 36°F to 46°F (2°C to 8°C). Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.

Precautions While Using Trimix:

Do not take Trimix Injection with any of the following medications: hypersensitivity or allergy to any component of this formulation; conditions predisposing you to priapism (painful erection lasting 4 hours or more): sickle cell anemia, multiple myeloma or leukemia; anatomical deformation of the penis or penile implants; direction by your physician that sexual activity is inadvisable or contraindicated. Tell your doctor if you have a condition or are taking a medicine that interferes with blood clotting.


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