Male Hypogonadism: Symptoms, Causes and Treatment of It

Male Hypogonadism: Symptoms, Causes and Treatment of It


Male Hypogonadism is when the body isn’t able to produce adequate testosterone. Moreover, testosterone is important for male development and growth during puberty and enough sperm, or both.

Male Hypogonadism can be inherited or develop gradually in life due to an injury or infection. The consequences — and what you can do regarding them vary depending on the cause and when male Hypogonadism strikes.

Hypogonadism can affect a variety of organ functioning and one’s quality of life.

The signs and symptoms vary depending on when the deficit first appears, the severity of the deficiency or the testes’ major functions affected.

Puberty does not advance if Hypogonadism happens before puberty. Male infertility and sexual dysfunction may result if it occurs after puberty. Also, symptoms of low testosterone in adult men appear in a few weeks of the initiation of the condition.

This article will cover everything about Male Hypogonadism.

Symptoms, Types, and Causes of Hypogonadism

At first, we will be covering the symptoms of Hypogonadism.

Symptoms of Hypogonadism

There can be a wide range of symptoms due to the lack of testosterone.

These depend on:

  • the age of initiation of testosterone deficiency
  • the severity of testosterone deficiency
  • how long has the loss been going on

Youthful adults and teens who have not yet reached puberty seem to be younger than their actual age.

Small genitalia, an absence of facial hair, an inability to intensify the voice, and trouble gaining muscle mass, even with workouts, are possible symptoms.

Hypogonadism that develops during puberty can cause:

  • impaired sexual development
  • decreased size of testicular
  • breasts that have grown in size

Adult-onset has the following symptoms:

  • erectile dysfunction
  • sperm count is low
  • lethargy
  • depressed mood
  • Low libido and sex drive
  • loss of body hair which includes pubic, axillary, facial
  • disturbances in sleep
  • a rise in body fat
  • breast enlargement and discomfort
  • flashes of heat
  • sweating
  • loss of concentration and energy
  • reduced bone mineral density and osteoporosis

Types of Hypogonadism

Hypogonadism is of two types:

  • Primary hypogonadism
  • Central hypogonadism

Primary hypogonadism

Primary hypogonadism is when your body can not produce enough sex hormones due to gonad issues. Your gonads are still receiving messages from your brain in order to produce hormones. They are, nevertheless, incapable of producing.

Central hypogonadism

In the case of central hypogonadism, the source of the problem is your brain. Your gonads aren’t functioning correctly because your hypothalamus and pituitary gland isn’t working properly.

Causes of Hypogonadism

An inherited (congenital) characteristic or something that occurs later on in life (acquired), like an injury or infection, can end up causing either type of hypogonadism. Moreover, primary and secondary hypogonadism can occur simultaneously.

 Causes of Primary Hypogonadism

Klinefelter syndrome: A congenital condition of the X and Y chromosomes causes this syndrome. A  male has one X and one Y chromosome. Klinefelter syndrome is characterized by the presence of two or more X chromosomes as well as one Y chromosome.

The Y chromosome is where the genetic information that determines a child’s sex. The extra X chromosome in Klinefelter syndrome impacts the usual testicular development, resulting in testosterone deficiency.


Undescended testicles:  In Cryptorchidism or Undescended testicles condition testicles advance within the abdomen before birth and usually move down into their original position in the scrotum. Either or both of the testicles may not be devolved when a child is born.

Without any treatment, this situation often rectifies itself within a few years of life. If no there is no treatment in childhood, it can result in testicular dysfunction and decreased testosterone creation.

Cancer Treatment: Chemotherapy and radiation therapy for treating cancer can disrupt testosterone and sperm production. Both treatments have temporary effects, but permanent infertility is possible.

hypogonadism in male

Causes of Secondary Hypogonadism

The testicles are ordinary in secondary hypogonadism. However, they do not function normally due to a pituitary or hypothalamic problem. Secondary hypogonadism can result from a number of factors, such as:

Kallmann’s syndrome: This refers to abnormal development of the brain region that regulates pituitary hormone production (hypothalamus). This condition can impair one’s ability to smell (anosmia) and lead to red-green colour blindness.

Pituitary disorders: A pituitary gland disorder can hinder hormone release from the pituitary gland to the testicles. As a result, this affects regular testosterone production. A pituitary tumour or any type of brain tumour near the pituitary gland can cause testosterone or any other hormone deficiencies.

HIV/AIDS: HIV/AIDS can end up causing low testosterone levels by impacting the hypothalamus, testes, and pituitary.

Diagnosis and Treatment of Hypogonadism

First, we will go through the diagnosis.

Hypogonadism Diagnosis

Early detection in boys can help avoid issues associated with delayed puberty. Men who start receiving timely diagnosis and treatment are more likely to be protected from osteoporosis and other related conditions.

Your doctor will perform a physical exam to ensure that your sexual development is appropriate for your age. They might look at your muscle mass, body hair, and sexual organs.

For diagnosis, the doctors can follow:

Hormone Tests

If you have signs and symptoms of hypogonadism, your doctor will check the testosterone levels in your blood. Since testosterone levels differ and are especially high in the early hours, a blood test is usually performed early in the day, before 10 a.m., on multiple days if possible.

If tests indicate that your testosterone levels are low, further testing can ascertain whether the cause is a testicular disorder or a pituitary anomaly. These studies could include the following:

  • Hormone analysis
  • Analysis of sperm
  • Pituitary Imaging
  • Genetic research
  • Biopsy of the testicles

Treatment for Hypogonadism in Male

Male hypogonadism is commonly treated with testosterone replacement therapy in order to restore testosterone levels back to normal. Testosterone can assist in combating male hypogonadism symptoms. This includes decreased sexual desire, decreased energy, reduced facial and body hair, and a decrease in muscle mass and bone density. TTT can be administered by injections into the muscle at regular intervals, or rub clear gel containing testosterone, or using a skin patch containing testosterone on your body at night time.

The perks of testosterone replacement for older men with low testosterone and symptoms and signs of hypogonadism due to ageing are less evident.

Your health care provider supervises you for treatment efficacy and side effects numerous times within your first year of treatment and then once a year after that.

Treatment for boys

Your doctor will conduct a physical exam to verify that your sexual development is age-appropriate. They may examine your muscle mass, hair, and sexual organs.

The cause of delayed puberty in boys determines the treatment. Testosterone injections for months can accelerate puberty and the advancement of secondary sexual characteristics like beard and pubic hair growth, muscle mass gain, and penis development.

Bottom Line

Male hypogonadism is becoming more widely recognized. Yet many adult men with the disorder go undetected and untreated. This may have a negative effect on both the living standards and the longevity of males.

Any male who suspects he has low testosterone levels should seek medical attention, as treatment can reverse the majority of the symptoms and risks associated with male hypogonadism.

However, before beginning TRT treatment, all men must analyze the benefits and risks with their doctor.

You can also consult with our doctors at Ohman. Ohman is a platform that provides you with the proper guidance and Medicines like erectile dysfunction medicines, Low Libido, Performance Anxiety, semen problems, and Male infertility Medicine. All of that is just a click away from you. Just go to Ohman. in and clear all your doubts.

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